Concentrations and Intermediary Metabolism in Euthyroid Humans

Context: 3,5-DiiodoL -thyronine (3,5-T 2 ) is a thyroid hormone metabolite which exhibited versatile effects in rodent models, including the prevention of insulin resistance or hepatic steatosis typically forced by a high-fat diet. With respect to euthyroid humans, we recently observed a putative link between serum 3,5-T 2 and glucose but not lipid metabolism. Objective: The aim of the present study was to widely screen the urine metabolome for associations with serum 3,5-T 2 concentrations in healthy individuals. Study Design and Methods: Urine metabolites of 715 euthyroid participants of the population-based Study of Health in Pomerania (SHIP-TREND) were analyzed by 1 H-NMR spectroscopy. Multinomial logistic and multivariate linear regression models were used to detect associations between urine metabolites and serum 3,5-T 2 concentrations. Results: Serum 3,5-T 2 concentrations were positively associated with urinary levels of trigonelline, pyroglutamate, acetone and hippurate. In detail, the odds for intermediate or suppressed serum 3,5-T 2 Received: November 3, 2014 Accepted after revision: February 24, 2015 Published online: May 28, 2015 Maik Pietzner Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald, Ferdinand-Sauerbruch Strasse DE–17475 Greifswald (Germany) E-Mail maik.pietzner @ uni-greifswald.de © 2015 European Thyroid Association Published by S. Karger AG, Basel 2235–0640/15/0045–0092$39.50/0